RWDD3 anticorps (N-Term)

N° du produit ABIN6991194

Détail du produit anti-RWDD3 anticorps

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RWDD3 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: RWDD3 Antibody is affinity chromatography purified via peptide column.

Immunogène: RWDD3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human RWDD3. The immunogen is located within the first 50 amino acids of RWDD3.

Isotype: IgG

Information d'application

Indications d'application: RWDD3 antibody can be used for detection of RWDD3 by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: RWDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: RWDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur RWDD3

Antigène: RWDD3 (RWD Domain Containing 3 (RWDD3))

Autre désignation: RWDD3 (RWDD3 Produits)

Synonymes: anticorps DKFZp469N1913, anticorps RSUME, anticorps 2510027J23Rik, anticorps 3110037C01Rik, anticorps AI035684, anticorps AI662458, anticorps X2CR1, anticorps X2cr1, anticorps zgc:73229, anticorps RWD domain containing 3, anticorps RWDD3, anticorps rwdd3, anticorps Rwdd3

Sujet: RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Iκ,Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-α,-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Iκ,Beta increased stability. RSUME-enhanced sumoylation of Iκ,Beta leads to the inhibition of NF-κ,Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

ID gène: 25950

NCBI Accession: NP_056300

UniProt: Q9Y3V2