FRMPD2 anticorps (N-Term)

N° du produit ABIN6991212

Détail du produit anti-FRMPD2 anticorps

Antigène: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Épitope: AA 80-130, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRMPD2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: FRMPD2 Antibody is affinity chromatography purified via peptide column.

Immunogène: FRMPD2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FRMPD2. The immunogen is located within amino acids 80 - 130 of FRMPD2.

Isotype: IgG

Information d'application

Indications d'application: FRMPD2 antibody can be used for detection of FRMPD2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: FRMPD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: FRMPD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur FRMPD2

Antigène: FRMPD2 (FERM and PDZ Domain Containing 2 (FRMPD2))

Autre désignation: FRMPD2 (FRMPD2 Produits)

Synonymes: anticorps Frmpd2, anticorps Gm1582, anticorps ENSMUSG00000071536, anticorps FRMPD2, anticorps PDZD5C, anticorps PDZK4, anticorps PDZK5C, anticorps FERM and PDZ domain containing 2, anticorps putative protein FRMPD2-like, anticorps FERM and PDZ domain-containing protein 2, anticorps Frmpd2, anticorps FRMPD2, anticorps LOC100051923, anticorps LOC100348282, anticorps LOC100548446

Sujet: FRMPD2 Antibody: The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.

ID gène: 143162

NCBI Accession: NP_001018081

UniProt: Q68DX3

Pathways: Cell-Cell Junction Organization