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CXXC4 anticorps (N-Term)

CXXC4 Reactivité: Humain, Souris, Rat WB, ELISA, IHC (p), IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6991438
  • Antigène Voir toutes CXXC4 Anticorps
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Épitope
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    AA 50-100, N-Term
    Reactivité
    • 22
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 21
    • 1
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CXXC4 est non-conjugé
    Application
    • 21
    • 16
    • 15
    • 14
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    CXXC4 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4. The immunogen is located within amino acids 50 - 100 of CXXC4.
    Isotype
    IgG
    Top Product
    Discover our top product CXXC4 Anticorps primaire
  • Indications d'application
    CXXC4 antibody can be used for detection of CXXC4 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    CXXC4 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    CXXC4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Autre désignation
    CXXC4 (CXXC4 Produits)
    Synonymes
    anticorps 9330210J02Rik, anticorps C030003J12Rik, anticorps Idax, anticorps IDAX, anticorps Xldax, anticorps xIdax, anticorps CXXC finger 4, anticorps CXXC finger protein 4, anticorps CXXC finger protein 4 S homeolog, anticorps Cxxc4, anticorps CXXC4, anticorps cxxc4.S
    Sujet
    CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
    ID gène
    80319
    NCBI Accession
    NP_079488
    UniProt
    Q9H2H0
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