GEMC1 anticorps (AA 130-180)

N° du produit ABIN6991546

Détail du produit anti-GEMC1 anticorps

Antigène: GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))

Épitope: AA 130-180

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GEMC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: GEMC1 Antibody is affinity chromatography purified via peptide column.

Immunogène: GEMC1 antibody was raised against a 19 amino acid synthetic peptide near the center of human GEMC1. The immunogen is located within amino acids 130 - 180 of GEMC1.

Isotype: IgG

Information d'application

Indications d'application: GEMC1 antibody can be used for detection of GEMC1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: GEMC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: GEMC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur GEMC1

Antigène: GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))

Autre désignation: GEMC1 (GMNC Produits)

Synonymes: anticorps GEMC1, anticorps Gemc1, anticorps Gm1778, anticorps Gm606, anticorps gemc1, anticorps xGEMC1, anticorps geminin coiled-coil domain containing, anticorps geminin coiled-coil domain containing S homeolog, anticorps GMNC, anticorps Gmnc, anticorps gmnc.S

Sujet: GEMC1 Antibody: The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.

ID gène: 647309

NCBI Accession: NP_001140158

UniProt: A6NCL1