At least two isoforms of HIG2 are known to exist, this antibody will detect both isoforms. HIG2 antibody is predicted to not cross-react with HIG1
Purification
HIG2 Antibody is affinity chromatography purified via peptide column.
Immunogène
HIG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human HIG2. The immunogen is located within the last 50 amino acids of HIG2.
HILPDA
Reactivité: Humain, Souris
WB, EIA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
HIG2 antibody can be used for detection of HIG2 by Western blot at 1 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
HIG2 Antibody is supplied in PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C,4 °C
Stockage commentaire
HIG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
HIG2 Antibody: HIG1 and HIG2 (Hypoxia-inducible gene 1 and 2, respectively) are known to be induced by hypoxic conditions. HIG2 is induced by hypoxia and by glucose deprivation in cultured cells. In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen. Unlike HIG2, which is ubiquitously expressed and might be an activator and target of the canonical Wnt pathway, the function and the mechanisms underlying its regulation of HIG1 still remained unknown. The putative link between hypoxia and an oncogenic signaling pathway might play an important role in tumorigenesis.