At least three isoforms of RC3H1 are known to exist, this antibody will detect all three isoforms.
Purification
RC3H1 Antibody is affinity chromatography purified via peptide column.
Immunogène
Rabbit polyclonal RC3H1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RC3H1. The immunogen is located within amino acids 1040 - 1090 of RC3H1.
RC3H1
Reactivité: Humain
WB, ELISA, IHC
Hôte: Lapin
Polyclonal
Biotin
Indications d'application
RC3H1 antibody can be used for detection of RC3H1 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
RC3H1 Antibody is supplied in PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C,4 °C
Stockage commentaire
RC3H1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Antigène
RC3H1
(Ring Finger and CCCH-Type Domains 1 (RC3H1))
anticorps RNF198, anticorps ROQUIN, anticorps RC3H1, anticorps si:dkey-192m14.4, anticorps 5730557L09Rik, anticorps Gm551, anticorps N28103, anticorps mKIAA2025, anticorps RGD1563512, anticorps rc3h1, anticorps ring finger and CCCH-type domains 1, anticorps ring finger and CCCH-type domains 1a, anticorps ring finger and CCCH-type zinc finger domains 1, anticorps RING CCCH (C3H) domains 1, anticorps ring finger and CCCH-type domains 1 L homeolog, anticorps RC3H1, anticorps rc3h1a, anticorps Rc3h1, anticorps rc3h1.L
Sujet
RC3H1 Antibody: The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.