KREMEN1 anticorps (C-Term)

N° du produit ABIN6991831

Détail du produit anti-KREMEN1 anticorps

Antigène: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KREMEN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: Three isoforms of KREMEN1 exists as a result of alternative splicing event.

Purification: KREMEN1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1. The immunogen is located within the last 50 amino acids of KREMEN1.

Isotype: IgG

Information d'application

Indications d'application: KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.125 - 0.25 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: KREMEN1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: KREMEN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur KREMEN1

Antigène: KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))

Autre désignation: KREMEN1 (KREMEN1 Produits)

Synonymes: anticorps KREMEN1, anticorps krm1, anticorps kremen, anticorps kremem1, anticorps KREMEN, anticorps KRM1, anticorps AV002070, anticorps Kremen, anticorps Krm1, anticorps si:ct737139.1, anticorps si:dkeyp-7c9.1, anticorps kringle containing transmembrane protein 1, anticorps kringle containing transmembrane protein 1 S homeolog, anticorps KREMEN1, anticorps kremen1, anticorps Kremen1, anticorps kremen1.S

Sujet: KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.

Poids moléculaire: 54 kDa

ID gène: 83999

NCBI Accession: NP_114434

UniProt: Q96MU8

Pathways: Signalisation WNT