SHISA3 anticorps (AA 120-170)

N° du produit ABIN6991837

Détail du produit anti-SHISA3 anticorps

Antigène: SHISA3 (Shisa Homolog 3 (SHISA3))

Épitope: AA 120-170

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHISA3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: SHISA3 antibody is predicted to not cross-react with other SHISA protein family members.

Purification: SHISA3 Antibody is affinity chromatography purified via peptide column.

Immunogène: SHISA3 antibody was raised against a 15 amino acid peptide near the center of human SHISA3 . The immunogen is located within amino acids 120 - 170 of SHISA3.

Isotype: IgG

Information d'application

Indications d'application: SHISA3 Antibody can be used for detection of SHISA3 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SHISA3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SHISA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur SHISA3

Antigène: SHISA3 (Shisa Homolog 3 (SHISA3))

Autre désignation: SHISA3 (SHISA3 Produits)

Synonymes: anticorps hShisa3, anticorps D830007B15Rik, anticorps shisa family member 3, anticorps SHISA3, anticorps Shisa3

Sujet: SHISA3 Antibody: SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

Poids moléculaire: Predicted: 26 kDa

Observed: 28 kDa

ID gène: 152573

NCBI Accession: NP_001073974

UniProt: A0PJX4