WAC anticorps (AA 210-260)

N° du produit ABIN6991845

Détail du produit anti-WAC anticorps

Antigène: WAC (WW Domain Containing Adaptor with Coiled-Coil (WAC))

Épitope: AA 210-260

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WAC est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: At least two isoforms of WAC are known to exist, this antibody will detect the larger isoform.

Purification: WAC Antibody is affinity chromatography purified via peptide column.

Immunogène: WAC antibody was raised against a 19 amino acid peptide near the center of human WAC . The immunogen is located within amino acids 210 - 260 of WAC.

Isotype: IgG

Information d'application

Indications d'application: WAC Antibody can be used for detection of WAC by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: WAC Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: WAC antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur WAC

Antigène: WAC (WW Domain Containing Adaptor with Coiled-Coil (WAC))

Autre désignation: WAC (WAC Produits)

Synonymes: anticorps BM-016, anticorps PRO1741, anticorps Wwp4, anticorps 1110067P07Rik, anticorps A230035H12Rik, anticorps AI256735, anticorps AI256776, anticorps DKFZp468H162, anticorps wac, anticorps wu:fc13f04, anticorps wu:fj68f01, anticorps zgc:55755, anticorps RGD1562407, anticorps zgc:101828, anticorps WW domain containing adaptor with coiled-coil, anticorps WW domain containing adaptor with coiled-coil a, anticorps WW domain containing adaptor with coiled-coil b, anticorps WAC, anticorps Wac, anticorps wac, anticorps waca, anticorps wacb

Sujet: WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.

Poids moléculaire: Predicted: 71 kDa

Observed: 75 kDa

ID gène: 51322

NCBI Accession: NP_057712

UniProt: Q9BTA9

Pathways: Chromatin Binding