Western Blotting (WB), ELISA, Immunofluorescence (IF)
Specificité
PHF14 antibody is human, mouse and rat reactive. Multiple isoforms of PHF14 are known to exist.
Purification
PHF14 Antibody is affinity chromatography purified via peptide column.
Immunogène
PHF14 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHF14. The immunogen is located within amino acids 210 - 260 of PHF14 .
PHF14, a novel plant homology domain (PHD) transcription factor, controls the proliferation of mesenchymal cells by regulating PDGFR alpha expression in embryonic development (1). PHD finger transcription factors are concerned with transcriptional regulation by interacting with modified histones (2), and dysregulation of several genes encoding PHD finger transcription factors, such as ING1 and RBP2, has been found in human cancer diseases suggesting these factors have an important role for cancer cell proliferation. PHF14 is a potential target for new treatments of lung fibrosis (1, 3).