PHC3 anticorps (N-Term)

N° du produit ABIN6991943

Détail du produit anti-PHC3 anticorps

Antigène: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Épitope: AA 240-290, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHC3 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: PHC3 antibody is human, mouse and rat specific. At least six isoforms of PHC3 are known to exist.

Purification: PHC3 antibody is affinity chromatography purified via peptide column.

Immunogène: PHC3 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHC3. The immunogen is located within amino acids 240 - 290 of PHC3.

Isotype: IgG

Information d'application

Indications d'application: PHC3 antibody can be used for detection of PHC3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PHC3 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PHC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur PHC3

Antigène: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Autre désignation: PHC3 (PHC3 Produits)

Synonymes: anticorps EDR3, anticorps HPH3, anticorps E030046K01Rik, anticorps Edr3, anticorps Hph3, anticorps polyhomeotic homolog 3, anticorps polyhomeotic-like 3 (Drosophila), anticorps Phc3, anticorps PHC3

Sujet: Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1). PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex (2). PRC1 complex acts via chromatin remodeling and modification of histones. PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3). PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4).

Poids moléculaire: Predicted: 109 kDa

Observed: 120 kDa

ID gène: 80012

NCBI Accession: NP_079223

UniProt: Q8NDX5