DIRAS3 anticorps (C-Term)

N° du produit ABIN6992120

Détail du produit anti-DIRAS3 anticorps

Antigène: DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIRAS3 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: DIRAS3 antibody is human specific.

Purification: DIRAS3 antibody is affinity chromatography purified via peptide column.

Immunogène: DIRAS3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DIRAS3. The immunogen is located within the last 50 amino acids of DIRAS3.

Isotype: IgG

Information d'application

Indications d'application: DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DIRAS3 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DIRAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur DIRAS3

Antigène: DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))

Autre désignation: DIRAS3 (DIRAS3 Produits)

Synonymes: anticorps DIRAS3, anticorps arhi, anticorps noey2, anticorps ARHI, anticorps NOEY2, anticorps DIRAS family GTPase 3, anticorps DIRAS family GTP binding RAS like 3, anticorps DIRAS3, anticorps diras3

Sujet: DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).

Poids moléculaire: Predicted: 25 kDa

Observed: 24 kDa

ID gène: 9077

NCBI Accession: NP_004666

UniProt: O95661