IZUMO1 anticorps (AA 170-220)

N° du produit ABIN6992154

Détail du produit anti-IZUMO1 anticorps

Antigène: IZUMO1 (Izumo Sperm-Egg Fusion 1 (IZUMO1))

Épitope: AA 170-220

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IZUMO1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: IZUMO1 antibody is human specific. At least four isoforms of IZUMO1 are known to exist, this antibody will detect the two longest isoforms.

Purification: IZUMO1 antibody is affinity chromatography purified via peptide column.

Immunogène: IZUMO1 antibody was raised against an 18 amino acid peptide near the center of human IZUMO1. The immunogen is located within amino acids 170 - 220 of IZUMO1.

Isotype: IgG

Information d'application

Indications d'application: IZUMO1 antibody can be used for detection of IZUMO1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IZUMO1 antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IZUMO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur IZUMO1

Antigène: IZUMO1 (Izumo Sperm-Egg Fusion 1 (IZUMO1))

Autre désignation: IZUMO1 (IZUMO1 Produits)

Synonymes: anticorps IZUMO, anticorps 1700058F15Rik, anticorps Izumo, anticorps izumo sperm-egg fusion 1, anticorps Ras interacting protein 1, anticorps IZUMO1, anticorps RASIP1, anticorps Izumo1

Sujet: IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2). IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3). Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4).

Poids moléculaire: Predicted: 35, 39, 42 kDa

Observed: 52 kDa

ID gène: 284359

NCBI Accession: NP_872381

UniProt: Q8IYV9