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SARS-CoV-2 ORF3a anticorps (N-Term)

Reactivité: SARS Coronavirus-2 (SARS-CoV-2) ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6992301
  • Antigène Tous les produits SARS-CoV-2 ORF3a
    SARS-CoV-2 ORF3a
    Épitope
    • 2
    • 1
    N-Term
    Reactivité
    SARS Coronavirus-2 (SARS-CoV-2)
    Hôte
    • 2
    • 1
    Lapin
    Clonalité
    • 3
    Polyclonal
    Conjugué
    • 3
    Cet anticorp SARS-CoV-2 ORF3a est non-conjugé
    Application
    ELISA, Immunohistochemistry (IHC)
    Purification
    SARS-CoV-2 (COVID-19) ORF3a Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Anti-SARS-CoV-2 (COVID-19) ORF3a antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of SARS-CoV-2 (COVID-19) ORF3a protein. The immunogen is located within the first 50 amino acids of the SARS-CoV-2 (COVID-19) ORF3a protein.
    Isotype
    IgG
  • Indications d'application
    IHC: 0.2 μ,g/mL Antibody validated: Immunohistochemistry in human samples. Antibody validated: SARS-CoV-2 (COVID-19) ORF3a antibody can detect 2 ng of free peptide at 1 μ,g/mL in ELISA. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SARS-CoV-2 (COVID-19) ORF3a antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    SARS-CoV-2 (COVID-19) ORF3a antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    SARS-CoV-2 ORF3a
    Abstract
    SARS-CoV-2 ORF3a Produits
    Synonymes
    anticorps ORF3a protein, anticorps ORF3a
    Classe de substances
    Viral Protein
    Sujet
    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). SARS-CoV-2 virus proteins include structural proteins, non-structural proteins and accessory factors. The structure of SARS-CoV-2 consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. SARS-CoV-2 non-structural protein is ORF1ab that consists of 16 proteins (nsp1-nsp16), while accessory factors include ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10. ORF3a forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. It up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. It induces apoptosis in cell culture and downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination (3).
    ID gène
    43740569
    UniProt
    P0DTC3
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