IL-6 Receptor anticorps

N° du produit ABIN7234279

Détail du produit anti-IL-6 Receptor anticorps

Antigène: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-6 Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen Affinity Purification

Immunogène: Recombinant Human Interleukin-6 receptor subunit alpha protein

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-1:2000 IHC 1:100-1:300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.05 % Proclin300 and 50 % glycerol, pH 7.4.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IL-6 Receptor

Antigène: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Autre désignation: IL6R (IL6R Produits)

Synonymes: anticorps IL6R, anticorps il-6ra, anticorps CD126, anticorps IL-6R-1, anticorps IL-6RA, anticorps IL6Q, anticorps IL6RA, anticorps IL6RQ, anticorps gp80, anticorps IL6R1, anticorps Il6ra, anticorps IL-6Ralpha, anticorps IL-6R, anticorps Il6r, anticorps interleukin 6 receptor, anticorps interleukin 6 receptor, alpha, anticorps IL6R, anticorps il6r, anticorps Il6r, anticorps Il6ra

Sujet: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Poids moléculaire:

Observed_MW: 80 kDa

Calculated_MW: 40,51 kDa

UniProt: P08887

Pathways: Signalistation JAK/STAT, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints