anticorps aplp, anticorps MGC115336, anticorps APLP, anticorps Aplp1_retired, anticorps RGD1561211, anticorps amyloid beta precursor like protein 1, anticorps amyloid beta precursor like protein 1 L homeolog, anticorps amyloid beta (A4) precursor-like protein 1, anticorps APLP1, anticorps aplp1.L, anticorps aplp1, anticorps Aplp1
Sujet
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.