SRGAP3 anticorps

N° du produit ABIN7237712

Détail du produit anti-SRGAP3 anticorps

Antigène: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRGAP3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant protein of human SRGAP3

Isotype: IgG

Information d'application

Indications d'application: IHC 1:25-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SRGAP3

Antigène: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Autre désignation: SRGAP3 (SRGAP3 Produits)

Synonymes: anticorps AI452337, anticorps Arhgap14, anticorps D130026O08Rik, anticorps Gbi, anticorps MEGAP, anticorps WRP, anticorps mKIAA0411, anticorps RGD1563152, anticorps ARHGAP14, anticorps SRGAP2, anticorps RGD1566016, anticorps srGAP2, anticorps fnbp2, anticorps srgap2, anticorps SLIT-ROBO Rho GTPase activating protein 3, anticorps SLIT-ROBO Rho GTPase activating protein 2, anticorps SLIT-ROBO Rho GTPase activating protein 2 L homeolog, anticorps Srgap3, anticorps SRGAP3, anticorps Srgap2, anticorps srgap3, anticorps srgap2.L

Sujet: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.

UniProt: O43295