ERN2 anticorps

N° du produit ABIN7238930

Détail du produit anti-ERN2 anticorps

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Synthetic peptide of human ERN2

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ERN2

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Autre désignation: ERN2 (ERN2 Produits)

Synonymes: anticorps Ire1beta, anticorps ire1b, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps IRE1-BETA, anticorps IRE1b, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN2, anticorps ern2, anticorps Ern2

Sujet: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

NCBI Accession: NP_150296

UniProt: Q76MJ5