ERG anticorps

N° du produit ABIN7239971

Détail du produit anti-ERG anticorps

Antigène: ERG (ERG, ETS transcription factor (ERG))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERG est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant protein of human ERG

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ERG

Antigène: ERG (ERG, ETS transcription factor (ERG))

Autre désignation: ERG (ERG Produits)

Synonymes: anticorps erg-3, anticorps p55, anticorps erg, anticorps erg_A, anticorps zgc:103429, anticorps erg_E, anticorps ERG, anticorps D030036I24Rik, anticorps KCNH2, anticorps ERG, ETS transcription factor, anticorps v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog, anticorps v-ets avian erythroblastosis virus E26 oncogene homolog, anticorps v-ets avian erythroblastosis virus E26 oncogene homolog S homeolog, anticorps ETS transcription factor, anticorps potassium voltage-gated channel subfamily H member 6, anticorps ERG, anticorps Erg, anticorps erg.L, anticorps erg, anticorps erg.S, anticorps KCNH6

Sujet: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: 54 kDa

UniProt: P11308