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JMJD2D anticorps

KDM4D Reactivité: Humain, Rat, Souris ELISA, WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7002265
  • Antigène Voir toutes JMJD2D (KDM4D) Anticorps
    JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))
    Reactivité
    Humain, Rat, Souris
    Hôte
    • 33
    Lapin
    Clonalité
    • 33
    Polyclonal
    Conjugué
    • 16
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp JMJD2D est non-conjugé
    Application
    • 22
    • 17
    • 4
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogène
    Recombinant protein of human KDM4D
    Isotype
    IgG
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.2 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))
    Autre désignation
    KDM4D (KDM4D Produits)
    Synonymes
    anticorps JMJD2D, anticorps 4932416A15, anticorps Jmjd2d, anticorps KDM4D, anticorps lysine demethylase 4D, anticorps lysine-specific demethylase 4D, anticorps lysine (K)-specific demethylase 4D, anticorps KDM4D, anticorps LOC524768, anticorps Kdm4d, anticorps LOC617971, anticorps LOC100067461, anticorps LOC698455, anticorps LOC100514356
    Sujet
    JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.
    Poids moléculaire
    59 kDa
    UniProt
    Q6B0I6
    Pathways
    L'effet Warburg
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