anticorps NAPI-1, anticorps NPT-1, anticorps NPT1, anticorps Napi-1, anticorps Napi1, anticorps Npt1, anticorps solute carrier family 17 member 1, anticorps solute carrier family 17 (sodium phosphate), member 1, anticorps SLC17A1, anticorps Slc17a1
Sujet
NPT1, also called sodium-dependent phosphate transport protein, belongs to the organic anion transporter family, SLC17A. It is mainly expressed in the kidney transporting small organic anions such as PAH (para-aminohippurate), but it is also found in the liver and brain. NTP1 localizes to the apical membrane of renal proximal tubular cells and functions as a voltage driven organic anion/Cl-exchanger. It also plays a role in maintaining phosphate homeostasis. The expression of NPT1 is transcriptionally regulated by HNF-1 and HNF-3. Indomethacin and salicylate inhibit NPT1-mediated PAH transport.