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HLA-DOB anticorps

HLA-DOB Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7245230
  • Antigène Voir toutes HLA-DOB Anticorps
    HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
    Reactivité
    • 24
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 18
    • 6
    Lapin
    Clonalité
    • 21
    • 3
    Polyclonal
    Conjugué
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HLA-DOB est non-conjugé
    Application
    • 17
    • 8
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogène
    Synthetic peptide of human HLA-DOB
    Isotype
    IgG
  • Indications d'application
    WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.2 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    HLA-DOB (Major Histocompatibility Complex, Class II, DO beta (HLA-DOB))
    Autre désignation
    HLA-DOB (HLA-DOB Produits)
    Synonymes
    anticorps DOB, anticorps major histocompatibility complex, class II, DO beta, anticorps HLA-DOB, anticorps PATR-DOB
    Sujet
    HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.
    Poids moléculaire

    Observed_MW: Refer to figures

    Calculated_MW: 31 kDa

    UniProt
    P13765
    Pathways
    Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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