IMPA1 anticorps

N° du produit ABIN7246232

Détail du produit anti-IMPA1 anticorps

Antigène: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IMPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human IMPA1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IMPA1

Antigène: IMPA1 (Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))

Autre désignation: IMPA1 (IMPA1 Produits)

Synonymes: anticorps zgc:100926, anticorps 2610002K09Rik, anticorps 2900059K10Rik, anticorps AI325909, anticorps IMP, anticorps IMPA, anticorps impa, anticorps inositol monophosphatase 1, anticorps inositol(myo)-1(or 4)-monophosphatase 1, anticorps inositol (myo)-1(or 4)-monophosphatase 1, anticorps inositol monophosphatase, anticorps inositol(myo)-1(or 4)-monophosphatase 1 S homeolog, anticorps impa1, anticorps Impa1, anticorps IMPA1, anticorps impa1.S

Sujet: This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.

Poids moléculaire:

Observed_MW: Refer to figures

Calculated_MW: 30 kDa

UniProt: P29218