HLA-DRB4 anticorps
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- Antigène Voir toutes HLA-DRB4 Anticorps
- HLA-DRB4 (Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4))
- Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HLA-DRB4 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogène
- Fusion protein of human HLA-DRB4
- Isotype
- IgG
- Top Product
- Discover our top product HLA-DRB4 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:20-1:100, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.02 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- HLA-DRB4 (Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4))
- Autre désignation
- HLA-DRB4 (HLA-DRB4 Produits)
- Synonymes
- anticorps DR-4, anticorps DR4, anticorps DRB4, anticorps HLA-DR4B, anticorps major histocompatibility complex, class II, DR beta 4, anticorps HLA-DRB4
- Sujet
- HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
- Poids moléculaire
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Observed_MW: Refer to figures
Calculated_MW: 30 kDa
- UniProt
- P13762
- Pathways
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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