HUS1 anticorps

N° du produit ABIN7246571

Détail du produit anti-HUS1 anticorps

Antigène: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HUS1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human HUS1

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.14 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HUS1

Antigène: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Autre désignation: HUS1 (HUS1 Produits)

Synonymes: anticorps hHUS1, anticorps mHus1, anticorps XHus1, anticorps hus1, anticorps HUS1 checkpoint clamp component, anticorps checkpoint clamp complex protein Hus1, anticorps HUS1 checkpoint clamp component L homeolog, anticorps HUS1, anticorps Hus1, anticorps hus1, anticorps hus1.L

Sujet: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.

UniProt: O60921