PNRC2 anticorps

N° du produit ABIN7246772

Détail du produit anti-PNRC2 anticorps

Antigène: PNRC2 (Proline Rich Nuclear Receptor Coactivator 2 (PNRC2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PNRC2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human PNRC2

Isotype: IgG

Information d'application

Indications d'application: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.54 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PNRC2

Antigène: PNRC2 (Proline Rich Nuclear Receptor Coactivator 2 (PNRC2))

Autre désignation: PNRC2 (PNRC2 Produits)

Synonymes: anticorps 0610011E17Rik, anticorps D4Bwg0593e, anticorps wu:cegs2777, anticorps wu:fb51a04, anticorps wu:fb81a06, anticorps wu:fd19g06, anticorps proline rich nuclear receptor coactivator 2, anticorps proline-rich nuclear receptor coactivator 2, anticorps PNRC2, anticorps Pnrc2, anticorps pnrc2

Sujet: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).

UniProt: Q9NPJ4