NIPBL anticorps

N° du produit ABIN7246814

Détail du produit anti-NIPBL anticorps

Antigène: NIPBL (Nipped-B like Protein (NIPBL))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NIPBL est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Fusion protein of human NIPBL

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NIPBL

Antigène: NIPBL (Nipped-B like Protein (NIPBL))

Autre désignation: NIPBL (NIPBL Produits)

Synonymes: anticorps CDLS, anticorps CDLS1, anticorps IDN3, anticorps IDN3-B, anticorps Scc2, anticorps SCC2W, anticorps scc2, anticorps nipbl, anticorps scc2-2, anticorps NIPBL, anticorps nipbla, anticorps wu:fi33d08, anticorps 4921518A06Rik, anticorps 4933421G18Rik, anticorps C79399, anticorps Idn3, anticorps NIPBL, cohesin loading factor, anticorps Nipped-B homolog-like, anticorps NIPBL, cohesin loading factor S homeolog, anticorps nipped-B homolog b (Drosophila), anticorps nipped-B-like protein A, anticorps Nipped-B homolog (Drosophila), anticorps NIPBL, anticorps NIPBLL, anticorps nipbl.S, anticorps LOC427439, anticorps nipblb, anticorps LOC100164947, anticorps nipbl, anticorps Nipbl

Sujet: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q6KC79

Pathways: Sensory Perception of Sound, Stem Cell Maintenance