CBFA2T2 anticorps
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- Antigène Voir toutes CBFA2T2 Anticorps
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CBFA2T2 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Attributs du produit
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogène
- Fusion protein of human CBFA2T2
- Isotype
- IgG
- Top Product
- Discover our top product CBFA2T2 Anticorps primaire
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- Indications d'application
- WB 1:1000-1:5000, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.26 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
- Autre désignation
- CBFA2T2 (CBFA2T2 Produits)
- Synonymes
- anticorps MTGR1, anticorps A430091M07, anticorps C330013D05Rik, anticorps Cbfa2t2h, anticorps EHT, anticorps ZMYND3, anticorps p85, anticorps XETOR, anticorps cbfa2t2-a, anticorps CBFA2/RUNX1 translocation partner 2, anticorps core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human), anticorps CBFA2/RUNX1 translocation partner 2 L homeolog, anticorps Cbfa2t2, anticorps CBFA2T2, anticorps cbfa2t2.L
- Sujet
- In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
- Poids moléculaire
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Observed_MW: Refer to figures
Calculated_MW: 67 kDa
- UniProt
- O43439
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