Cullin 4A anticorps
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- Antigène Voir toutes Cullin 4A (CUL4A) Anticorps
- Cullin 4A (CUL4A)
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cullin 4A est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogène
- Synthetic peptide of human CUL4A
- Isotype
- IgG
- Top Product
- Discover our top product CUL4A Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.62 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- Cullin 4A (CUL4A)
- Autre désignation
- CUL4A (CUL4A Produits)
- Synonymes
- anticorps zgc:64071, anticorps CUL4A, anticorps 2810470J21Rik, anticorps AW495282, anticorps RGD1563853, anticorps cullin 4A, anticorps CUL4A, anticorps cul4a, anticorps Cul4a
- Sujet
- Cullin proteins assemble a large number of RING E3 ubiquitin ligases,participating in the proteolysis through the ubiquitin-proteasome pathway. Two cullin 4 (CUL4) proteins,CUL4A (87 kDa) and CUL4B(104 kDa),have been identified. The two CUL4 sequences are 83 % identical. They target certain proteins for degradation by binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex with DDB. They form two individual E3 ligases,DDB1-CUL4ADDB2 and DDB1-CUL4BDDB2 in this process. CUL4A appeared in both the nucleus and the cytosol,suggesting a more complex mechanism for entering the nucleus. CUL4B is localized in the nucleus and facilitates the transfer of DDB1 into the nucleus independently of DDB2.
- Poids moléculaire
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Observed_MW: Refer to figures
Calculated_MW: 88 kDa
- UniProt
- Q13619
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