HIPK3 anticorps

N° du produit ABIN7247966

Détail du produit anti-HIPK3 anticorps

Antigène: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIPK3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of human HIPK3

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HIPK3

Antigène: HIPK3 (Homeodomain Interacting Protein Kinase 3 (HIPK3))

Autre désignation: HIPK3 (HIPK3 Produits)

Synonymes: anticorps HIPK3, anticorps pky, anticorps yak1, anticorps dyrk6, anticorps fist3, anticorps MGC145460, anticorps DYRK6, anticorps FIST3, anticorps PKY, anticorps YAK1, anticorps ANPK, anticorps homeodomain interacting protein kinase 3, anticorps homeodomain interacting protein kinase 3 L homeolog, anticorps HIPK3, anticorps hipk3.L, anticorps hipk3, anticorps Hipk3

Sujet: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

UniProt: Q9H422