IDE anticorps

N° du produit ABIN7250134

Détail du produit anti-IDE anticorps

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IDE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Attributs du produit: Monoclonal Antibody

Purification: Protein A purification

Immunogène: Synthetic Peptide

Clone: 1H4

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-300, IF 1:100-1:300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur IDE

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Autre désignation: IDE (IDE Produits)

Synonymes: anticorps zgc:162603, anticorps IDE, anticorps 1300012G03Rik, anticorps 4833415K22Rik, anticorps AA675336, anticorps AI507533, anticorps INSDEGM, anticorps INSULYSIN, anticorps insulin degrading enzyme, anticorps insulin-degrading enzyme, anticorps metallopeptidase, anticorps IDE, anticorps ide, anticorps LOC591315, anticorps CC1G_01115, anticorps Bm1_26615, anticorps PTRG_10875, anticorps SJAG_01430, anticorps EBI_21700, anticorps VDBG_06702, anticorps LOAG_08082, anticorps PGTG_04982, anticorps Tsp_00424, anticorps Ide

Sujet: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Poids moléculaire: 118 kDa

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome