RAN anticorps

N° du produit ABIN7255065

Détail du produit anti-RAN anticorps

Antigène: RAN (RAN, Member RAS Oncogene Family (RAN))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAN est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human RAN (NP_006316.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RAN

Antigène: RAN (RAN, Member RAS Oncogene Family (RAN))

Autre désignation: RAN (RAN Produits)

Synonymes: anticorps ARA24, anticorps Gsp1, anticorps TC4, anticorps ran, anticorps ara24, anticorps gsp1, anticorps ran-1, anticorps tc4, anticorps RAN, anticorps RANP1, anticorps AAF30287, anticorps CG1404, anticorps Dmel\CG1404, anticorps Ran, anticorps dran, anticorps l(1)G0075, anticorps ran10A, anticorps fc16b04, anticorps wu:fc16b04, anticorps RAN, member RAS oncogene family, anticorps RAN, member RAS oncogene family S homeolog, anticorps CG1404 gene product from transcript CG1404-RC, anticorps RAN, anticorps Ran, anticorps ran.S, anticorps ran

Sujet: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Poids moléculaire:

Observed_MW: 23 kDa

Calculated_MW: 24 kDa

ID gène: 5901

UniProt: P62826

Pathways: Regulatory RNA Pathways, Intracellular Steroid Hormone Receptor Signaling Pathway, Protein targeting to Nucleus