PYCARD anticorps

N° du produit ABIN7255624

Détail du produit anti-PYCARD anticorps

Antigène: PYCARD (PYD and CARD Domain Containing (PYCARD))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PYCARD est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human ASC / TMS1 (NP_037390.2).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PYCARD

Antigène: PYCARD (PYD and CARD Domain Containing (PYCARD))

Autre désignation: ASC / TMS1 (PYCARD Produits)

Synonymes: anticorps ASC, anticorps CARD5, anticorps TMS, anticorps TMS-1, anticorps TMS1, anticorps 9130417A21Rik, anticorps Asc, anticorps TNS1, anticorps masc, anticorps asc1, anticorps zAsc, anticorps zgc:109874, anticorps PYD and CARD domain containing, anticorps PYCARD, anticorps Pycard, anticorps pycard

Sujet: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

ID gène: 29108

UniProt: Q9ULZ3

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome