Dual Specificity Phosphatase 3 (DUSP3) anticorps

N° du produit ABIN7255902

Détail du produit

Antigène: Dual Specificity Phosphatase 3 (DUSP3)

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human DUSP3 (NP_004081.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détail du antigène

Antigène: Dual Specificity Phosphatase 3 (DUSP3)

Autre désignation: DUSP3 (DUSP3 Produits)

Synonymes: anticorps dusp3, anticorps si:bz18k17.3, anticorps si:rp71-18k17.3, anticorps VHR, anticorps RGD1560049, anticorps 2210015O03Rik, anticorps 5031436O03Rik, anticorps T-DSP11, anticorps dual specificity phosphatase 3, anticorps dual specificity phosphatase 3b, anticorps dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related), anticorps DUSP3, anticorps dusp3b, anticorps Dusp3

Classe de substances: Viral Protein

Sujet: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Poids moléculaire:

Observed_MW: 20 kDa

Calculated_MW: 16 kDa/20 kDa

ID gène: 1845

UniProt: P51452

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades