HLA-B anticorps

N° du produit ABIN7256404

Détail du produit anti-HLA-B anticorps

Antigène: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: A synthetic peptide of human HLA-B (NP_005505.2).

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur HLA-B

Antigène: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Autre désignation: HLA-B (HLA-B Produits)

Synonymes: anticorps AS, anticorps HLAB, anticorps SPDA1, anticorps mhc1b, anticorps major histocompatibility complex, class I, B, anticorps major histocompatibility complex nonclassical class Ib L homeolog, anticorps HLA-B, anticorps BOLA-B, anticorps MAMU-B18, anticorps DKFZP469N1225, anticorps mhc1b.L

Sujet: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Poids moléculaire:

Observed_MW: 40 kDa

Calculated_MW: 40 kDa

ID gène: 3106

UniProt: P01889

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response