CASC5 anticorps

N° du produit ABIN7256628

Détail du produit anti-CASC5 anticorps

Antigène: CASC5 (Cancer Susceptibility Candidate 5 (CASC5))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASC5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human CASC5 (NP_733468.3).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur CASC5

Antigène: CASC5 (Cancer Susceptibility Candidate 5 (CASC5))

Autre désignation: CASC5 (CASC5 Produits)

Synonymes: anticorps AF15Q14, anticorps CT29, anticorps D40, anticorps KNL1, anticorps PPP1R55, anticorps Spc7, anticorps hKNL-1, anticorps hSpc105, anticorps 2310043D08Rik, anticorps 5730505K17Rik, anticorps Rad51, anticorps kinetochore scaffold 1, anticorps Kinetochore null protein 1, anticorps KNL1, anticorps Knl1, anticorps knl-1

Sujet: The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11,15)(q23,q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.

Poids moléculaire:

Observed_MW: 300 kDa

Calculated_MW: 195 kDa/205 kDa/262 kDa/265 kDa

ID gène: 57082

UniProt: Q8NG31

Pathways: Maintenance of Protein Location, Autophagy