Aminoacylase 1 anticorps

N° du produit ABIN7257008

Détail du produit anti-Aminoacylase 1 anticorps

Antigène: Aminoacylase 1 (ACY1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aminoacylase 1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human ACY1 (NP_001185824.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Aminoacylase 1

Antigène: Aminoacylase 1 (ACY1)

Autre désignation: ACY1 (ACY1 Produits)

Synonymes: anticorps si:zfos-226g1.1, anticorps zgc:55605, anticorps zgc:76955, anticorps acy1, anticorps acy1d, anticorps acylase, anticorps ACY1, anticorps ACY-1, anticorps ACY1D, anticorps 1110014J22Rik, anticorps Acy-1, anticorps Acy1a, anticorps Acy1b, anticorps aminoacylase 1, anticorps aminoacylase 1, gene 1 S homeolog, anticorps aminoacylase 1, gene 1, anticorps ACY1, anticorps acy1, anticorps acy1.1.S, anticorps acy1.1, anticorps Acy1

Sujet: This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

ID gène: 95

UniProt: Q03154