EFCAB4B anticorps

N° du produit ABIN7257401

Détail du produit anti-EFCAB4B anticorps

Antigène: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EFCAB4B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human CRACR2A (NP_001138430.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur EFCAB4B

Antigène: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Autre désignation: CRACR2A (EFCAB4B Produits)

Synonymes: anticorps CRACR2A, anticorps Gm1073, anticorps Gm462, anticorps calcium release activated channel regulator 2A, anticorps CRACR2A, anticorps Cracr2a

Sujet: Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Poids moléculaire:

Observed_MW: 45 kDa

Calculated_MW: 45 kDa/83 kDa

ID gène: 84766

UniProt: Q9BSW2