anticorps ICBP90, anticorps Np95, anticorps RNF106, anticorps hNP95, anticorps hUHRF1, anticorps AL022808, anticorps NP95, anticorps fb97f09, anticorps wu:fb97f09, anticorps zgc:63539, anticorps UHRF1, anticorps ubiquitin like with PHD and ring finger domains 1, anticorps ubiquitin-like, containing PHD and RING finger domains, 1, anticorps ubiquitin-like with PHD and ring finger domains 1, anticorps UHRF1, anticorps Uhrf1, anticorps uhrf1
Sujet
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.