MAP3K3 anticorps

N° du produit ABIN7258882

Détail du produit anti-MAP3K3 anticorps

Antigène: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K3 est non-conjugé

Application: Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human MAP3K3 (NP_976226.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MAP3K3

Antigène: MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

Autre désignation: MAP3K3 (MAP3K3 Produits)

Synonymes: anticorps MAPKKK3, anticorps MEKK3, anticorps AW548911, anticorps Mekk3, anticorps mKIAA4031, anticorps mitogen activated protein kinase kinase kinase 3, anticorps mitogen-activated protein kinase kinase kinase 3, anticorps Map3k3, anticorps MAP3K3, anticorps map3k3

Sujet: This gene product is a 626-amino acid polypeptide that is 96.5 % identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively, it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

ID gène: 4215

UniProt: Q99759

Pathways: Signalisation MAPK