anticorps ABC-1, anticorps ABC1, anticorps CERP, anticorps HDLDT1, anticorps TGD, anticorps ABCA1, anticorps Abc1, anticorps ATP-binding cassette A1, anticorps Arabidopsis thaliana ATP-binding cassette A1, anticorps AtABCA1, anticorps im:7136239, anticorps sb:cb407, anticorps wu:fa07e06, anticorps zgc:171581, anticorps ATP binding cassette subfamily A member 1, anticorps ATP-binding cassette, sub-family A (ABC1), member 1, anticorps ATP-binding cassette A1, anticorps ATP-binding cassette, sub-family A (ABC1), member 1B, anticorps ABCA1, anticorps Abca1, anticorps abca1, anticorps abca1b
Sujet
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.