Titin anticorps

N° du produit ABIN7259346

Détail du produit anti-Titin anticorps

Antigène: Titin (TTN)

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Titin est non-conjugé

Application: Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant Protein of human TTN.

Isotype: IgG

Information d'application

Indications d'application: IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Titin

Antigène: Titin (TTN)

Autre désignation: TTN (TTN Produits)

Synonymes: anticorps CMD1G, anticorps CMH9, anticorps CMPD4, anticorps EOMFC, anticorps HMERF, anticorps LGMD2J, anticorps MYLK5, anticorps TMD, anticorps 1100001C23Rik, anticorps 2310036G12Rik, anticorps 2310057K23Rik, anticorps 2310074I15Rik, anticorps AF006999, anticorps AV006427, anticorps D330041I19Rik, anticorps D830007G01Rik, anticorps L56, anticorps mdm, anticorps shru, anticorps UNC-22, anticorps titin, anticorps TTN, anticorps Ttn, anticorps titin, anticorps TTNLOC100620261

Sujet: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.

ID gène: 7273

UniProt: Q8WZ42