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F12 anticorps

F12 Reactivité: Humain, Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7259454
  • Antigène Voir toutes F12 Anticorps
    F12 (Coagulation Factor XII (F12))
    Reactivité
    • 76
    • 14
    • 11
    • 5
    • 1
    Humain, Souris
    Hôte
    • 58
    • 13
    • 10
    • 3
    Lapin
    Clonalité
    • 73
    • 10
    Polyclonal
    Conjugué
    • 48
    • 8
    • 8
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp F12 est non-conjugé
    Application
    • 52
    • 50
    • 17
    • 10
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Attributs du produit
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein of human F12 (NP_000496.2).
    Isotype
    IgG
    Top Product
    Discover our top product F12 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    F12 (Coagulation Factor XII (F12))
    Autre désignation
    F12 (F12 Produits)
    Synonymes
    anticorps HAE3, anticorps HAEX, anticorps HAF, anticorps FXII, anticorps coagulation factor XII, anticorps coagulation factor XII (Hageman factor), anticorps F12
    Sujet
    This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
    Poids moléculaire

    Observed_MW: 71 kDa

    Calculated_MW: 67 kDa

    ID gène
    2161
    UniProt
    P00748
    Pathways
    Système du Complément
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