ZCCHC3 anticorps
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- Antigène Tous les produits ZCCHC3
- ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ZCCHC3 est non-conjugé
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Application
- Immunofluorescence (IF)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human ZCCHC3 (NP_149080.2).
- Isotype
- IgG
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- Indications d'application
- IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- ZCCHC3 (Zinc Finger, C3HC-Type Containing 3 (ZCCHC3))
- Autre désignation
- ZCCHC3 (ZCCHC3 Produits)
- Synonymes
- anticorps C20orf99, anticorps 2810406K24Rik, anticorps zinc finger CCHC-type containing 3, anticorps zinc finger, CCHC domain containing 3, anticorps ZCCHC3, anticorps Zcchc3
- Sujet
- Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5.
- ID gène
- 85364
- UniProt
- Q9NUD5
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