NUAK1 anticorps
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- Antigène Voir toutes NUAK1 Anticorps
- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NUAK1 est non-conjugé
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Application
- Western Blotting (WB)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human NUAK1 (NP_055655.1).
- Isotype
- IgG
- Top Product
- Discover our top product NUAK1 Anticorps primaire
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- Indications d'application
- WB 1:200-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
- Autre désignation
- NUAK1 (NUAK1 Produits)
- Synonymes
- anticorps ARK5, anticorps AU014801, anticorps AW494241, anticorps B230104P22Rik, anticorps Omphk1, anticorps NUAK family kinase 1, anticorps NUAK family, SNF1-like kinase, 1, anticorps NUAK1, anticorps Nuak1
- Sujet
- NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
- Poids moléculaire
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Observed_MW: 74 kDa
Calculated_MW: 23 kDa/74 kDa
- ID gène
- 9891
- UniProt
- O60285
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