BIN1 anticorps

N° du produit ABIN7259755

Détail du produit anti-BIN1 anticorps

Antigène: BIN1 (Bridging Integrator 1 (BIN1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human BIN1 (NP_647601.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:20-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur BIN1

Antigène: BIN1 (Bridging Integrator 1 (BIN1))

Autre désignation: BIN1 (BIN1 Produits)

Synonymes: anticorps bin1, anticorps MGC53185, anticorps amph2, anticorps amphl, anticorps sh3p9, anticorps MGC76187, anticorps cb57, anticorps zgc:86701, anticorps BIN1, anticorps AMPH2, anticorps AMPHL, anticorps SH3P9, anticorps ALP-1, anticorps Amphl, anticorps BRAMP-2, anticorps bridging integrator 1, anticorps bridging integrator 1 S homeolog, anticorps bridging integrator 1b, anticorps BIN1, anticorps bin1.S, anticorps bin1, anticorps bin1b, anticorps Bin1

Sujet: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Poids moléculaire:

Observed_MW: 65 kDa

Calculated_MW: 45-64 kDa

ID gène: 274

UniProt: O00499