Cullin 2 anticorps

N° du produit ABIN7260691

Détail du produit anti-Cullin 2 anticorps

Antigène: Cullin 2 (CUL2)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 2 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human CUL2 (NP_001185708.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Cullin 2

Antigène: Cullin 2 (CUL2)

Autre désignation: CUL2 (CUL2 Produits)

Synonymes: anticorps cul2, anticorps Cullin-2, anticorps fj48a06, anticorps wu:fj48a06, anticorps cullin-2, anticorps LOC100221330, anticorps 1300003D18Rik, anticorps 4932411N15Rik, anticorps AI327301, anticorps mKIAA4106, anticorps ATCUL2, anticorps F22D16.2, anticorps F22D16_2, anticorps cullin 2, anticorps cullin 2, anticorps cullin-2, anticorps putative cullin-2 (cul-2), anticorps cullin 2 L homeolog, anticorps Cullin-2, anticorps cul2, anticorps CUL2, anticorps PTRG_05231, anticorps Smp_079740, anticorps LOC100550749, anticorps Cul2, anticorps cul2.L, anticorps cul-2

Sujet: Human CUL2 is an ortholog of nematode cul2. Michel and Xiong (1998) identified human CUL2 cDNAs and reported that the predicted protein is 745 amino acids long.Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, whicHuman, Mouseediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

ID gène: 8453

UniProt: Q13617

Pathways: M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interactome