DDB1 anticorps

N° du produit ABIN7260707

Détail du produit anti-DDB1 anticorps

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: A synthetic peptide of human DDB1

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:100 IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur DDB1

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Autre désignation: DDB1 (DDB1 Produits)

Synonymes: anticorps DDBA, anticorps UV-DDB1, anticorps XAP1, anticorps XPCE, anticorps XPE, anticorps XPE-BF, anticorps DDB1, anticorps xpe, anticorps ddba, anticorps xap1, anticorps xpce, anticorps xpe-bf, anticorps uv-ddb1, anticorps ddb1, anticorps 127kDa, anticorps AA408517, anticorps p127-Ddb1, anticorps damage specific DNA binding protein 1, anticorps damage-specific DNA binding protein 1, 127kDa, anticorps DNA damage-binding protein 1, anticorps damage-specific DNA binding protein 1, anticorps DDB1, anticorps ddb1, anticorps LOC100187356, anticorps Ddb1, anticorps ddb-1

Sujet: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

ID gène: 1642

UniProt: Q16531

Pathways: Réparation de l'ADN