GTF2H2 anticorps

N° du produit ABIN7261267

Détail du produit anti-GTF2H2 anticorps

Antigène: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GTF2H2 est non-conjugé

Application: Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: A synthetic peptide of human GTF2H2 (NP_001506.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur GTF2H2

Antigène: GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))

Autre désignation: GTF2H2 (GTF2H2 Produits)

Synonymes: anticorps 44kDa, anticorps BTF2 p44, anticorps BTF2-p44, anticorps Btf2p44, anticorps p44, anticorps BTF2, anticorps BTF2P44, anticorps T-BTF2P44, anticorps TFIIH, anticorps general transcription factor II H, polypeptide 2, anticorps general transcription factor IIH subunit 2, anticorps general transcription factor IIH, polypeptide 2, 44kDa, anticorps Gtf2h2, anticorps GTF2H2

Sujet: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs, however, no sequence data is currently available for the centromeric copy of the gene.

ID gène: 2966

UniProt: Q13888

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling