TYROBP anticorps

N° du produit ABIN7261337

Détail du produit anti-TYROBP anticorps

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYROBP est non-conjugé

Application: Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human TYROBP (NP_003323.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TYROBP

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Autre désignation: TYROBP (TYROBP Produits)

Synonymes: anticorps TYROBP, anticorps DAP12, anticorps tyrpbp, anticorps Karap, anticorps KARAP, anticorps PLOSL, anticorps Ly83, anticorps dap12, anticorps TYRO protein tyrosine kinase binding protein, anticorps Tyro protein tyrosine kinase binding protein, anticorps TYROBP, anticorps tyrobp, anticorps Tyrobp

Sujet: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

ID gène: 7305

UniProt: O43914